Protein Interaction Networks Link Schizophrenia Risk Loci to Synaptic Function
نویسندگان
چکیده
منابع مشابه
Protein Interaction Networks Link Schizophrenia Risk Loci to Synaptic Function
Schizophrenia is a severe and highly heritable psychiatric disorder affecting approximately 1% of the population. Genome-wide association studies have identified 108 independent genetic loci with genome-wide significance but their functional importance has yet to be elucidated. Here, we develop a novel strategy based on network analysis of protein-protein interactions (PPI) to infer biological ...
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A. Vazquez, A. Flammini, A. Maritan and A. Vespignani 1 Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA 2 International School for Advanced Studies (SISSA) and INFM, V. Beirut 2-4, 34014 Trieste, Italy 3 The Abdus Salam International Centre for Theoretical Physics, P.O. Box 586, 34100 Trieste, Italy and 4 Laboratoire de Physique Theorique (UMR du CNRS 8627), atiment 2...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2016
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbw035